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The Prostate: Part I – BNP What is situated below a body of water, has four zones and is commonly associated with venial pleasures. No it is not some romantic European city, but rather a walnut sized male organ that serves important procreative functions. It also happens to be an organ that plagues men as we age. This organ or gland is the prostate. This is the first of two articles on the male prostate. This article will focus on a disease process that affects older men, something we refer to as benign prostatic hyperplasia (BPH). BPH is a non-cancerous growth in the size of the prostate gland that impairs the flow of urine out of the bladder. The second article will focus of prostate cancer. But first a little about the small yet important male organ. The gland is located just below the bladder. It usually measures one inch by one-and-a-half inches (approximately the size of a walnut). It surrounds the urethra (the tube that takes urine out of the bladder). It is responsible for producing a fluid important in male sexual function. In the past the prostate was described as having “lobes”, but today we refer to it as having concentric zones. These zones are important both on an anatomical as well as histological level. We can separate pathology along these zones as well. For instance most all cancers occur in the peripheral zone while the benign process of enlargement occurs almost exclusively in the transitional zone (which only occupies about 5% of the total prostate volume). The prostate gland is also made up of different cell types. Cancer cells develop from the epithelial cells, but it is the interaction with stromal cells that is important in the behavior of the cancer. BPH develops from an interaction between these cells as well, but it is complex and poorly understood. Testosterone and other hormones and their interactions with this gland are hot topics of research in understanding prostate disease. The prostate gland produces most of what is found in the male ejaculate. The average volume is about 3 mL. This is less than a teaspoon and only 1% of it is sperm. The majority of the semen volume is made of products of the seminal vesicles and the prostate. The male ejaculate is very rich in potassium, zinc, citric acid and fructose. Along with these substances it also contains prostaglandins. There are many other unusual substances found in the semen. Not all is know about their function or purpose. This important male organ is a complex mix of anatomical structures and cell types that make it possible for human reproduction. However beyond the reproductive years of men, this organ becomes one of burden rather than usefulness. We will discuss the finer points of BPH and how to best avoid it and if plagued with it, treatment options. BPH typically affects men from their fourth to fifth decade of life and beyond. Several hormones come into play that have a drastic effect on the transitional zone (the zone that is most central and surrounding the urethra). Namely a metabolite of the male androgen Testosterone called Dihydrotestosterone (DHT) plays a big part on the enlargement of cells of the prostate and the encroachment on the urethra. There are several signs and symptoms that correlate with BPH and they are: slow urinary flow, the urge to urinate all the time, nighttime urination, enlargement and distension of the bladder with continuous urine leakage (incontinence) and urinary obstruction. Autopsies suggest that more than 90% of men older than 70 years have BPH. The average age for symptomatic development is about 65 years for white Americans and about 60 years for African-American men. Ways to prevent the effects of DHT on the prostate gland and the ensuing enlargement are via medications that block the enzyme 5-alpha-reductase, which converts Testosterone to DHT. Proscar is such a drug commercially available through a pharmaceutical company. Proscar works on blocking the effects of androgens on the epithelial cells and can actually shrink the size of the prostate making some of the symptoms of BPH resolve. Alternatively two FDA approved drugs that aid in symptoms of BPH (but act differently than Proscar) are Hytrin and Cardura. Both Hytrin and Cardura are drugs in the alpha1-blocker class. Originally researched as a centrally acting blood pressure reducer for patient with hypertension, it was discovered that this drug would actually relax the prostate tissue surrounding the urethra making symptoms of BPH resolve. Side effects generally include low blood pressure, dizziness, and nasal stuffiness. While neither of these two drugs will “cure” or reverse the process, they certainly do provide symptom relief for the patient plagued with BPH. Another way to treat this disease and a more natural approach is the use of herbs know for their anti-androgenic effects on the prostate. These include the well-studied Saw Palmetto herbal extract that blocks 5-alpha-reductase in the same manner as the prescription drug. Saw Palmetto taken in a standardized dose of 160mg twice daily has shown increased urine flow, with minimal side effects. Saw Palmetto is an herb indigenous to the Lowcountry of Georgia and South Carolina. Pygeum Africanum is shown to do the same yet it is not as effective and there is a fair degree of stomach symptoms. Pygeum is derived from an African evergreen tree. Stinging Nettles (Radix urticae) is another herb used widely in Europe for prostate health that has been shown to lower the residual urine volume in men with enlarged prostates. These phytotherapeutics (plant derived medicines), used and described by the Egyptians as far back as the 15 Century B.C., have a common compounds called phytosterols. The most effective phytosterol is beta sito sterol for BPH. None of the medications or herbs has been shown to prevent prostate cancer. These prescription medications and herbs are for the treatment, reduction in size or prevention of the benign process of enlargement of the prostate. Prostate cancer prevention and treatment is by other means and the subject of the next article. Besides the herbal and drug therapies there are a few surgical therapies worth mentioning. These include the most common transurethral resection of the prostate or TURP. This is where under the care of an urologist the constricted urethra within the prostate gland is “reamed out” thus mechanically or surgically widened the opening. A variant of this is the transurethral incision of the prostate (TUIP) where an incision rather than resection of the tissue is performed. A suitable procedure for patients with prostates 100 mL in volume. This involves an abdominal operation and removal of the whole prostate. Of course symptoms mentioned above for TURP are of greater frequency with this more radical procedure. There is also thermotherapy (a type of microwave treatment) that alleviates irritative symptoms, but not much is available in long-term results in the medical literature. And finally stent placement is an option. This can be used in selected cases of patients with a poor general condition and in the non-operative candidate. Symptoms of BPH include: Obstructive symptoms: Hesitancy in initiating voiding (trouble getting started) Weak urinary stream, prolonged voiding Post-voiding dribbling (mild incontinence) Sensation of incomplete emptying Nocturia (night time urination) Overflow incontinence Acute urinary retention (very painful condition) Irritative symptoms: Dysuria (discomfort in urination) Frequency Urgency Scoring BPH: The American Urological Association Symptom Index (AUASI) and International Prostate Symptom Score (IPSS) are now considered the gold standard measurement tools for the assessment of BPH symptoms and response to treatment. Both questionnaires can be used by a physician in a clinical practice to quantify the subjective symptoms of BPH and monitor therapies. Part II in this series will cover annual examination of the prostate, blood testing, prostate cancer. It will also cover prevention and treatment of prostate cancer. Reference: http://www.prostatehealth.com Lowe, FC. Et al, Phytotherapy in treatment of benign prostatic hyperplasia: a critical review. Urology 48:12-19, 1996 Dreikorn, K. et al, Stellenwert von Phytotherapeutica dei der Behandulng der benighnen Prostatahyperplasia. Urologe (A)34:119-129, 1995 Fitzpatrick, J.M. et al, Phytotherapeutic Agents in Management of Symptomatic Benign Prostatic Hyperplasia. Urological Clinics of North America. 22:407-412, 1995 Wilt T, Ishani A, Mac Donald R.. Serenoa repens for benign prostatic hyperplasia. The Cochrane Database of Systematic Reviews 2002, Issue 3. Art. No.: CD001423. DOI: 10.1002/14651858.CD001423. [Research by Sagalowski and Wilson, 1998] © 2005 penile enlargement doctor free penis enlargement exercise penis elargement cream vimax penis enlargement result cheap penis elargement pills penis enlargement program penile enlargement video vimax penis enlargement device

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Question: Have plastic food and beverage containers been proven safe? Answer: No. During the film's graduation party in THE GRADUATE, Mr. McGuire pulls Benjamin Braddock (Dustin Hoffman) aside to offer sage advice for his future. His future would be one word: "plastics." Of course, we all know Mr. McGuire's advice and prognostication was correct. Plastics can only be made by man in his infinite wisdom, hence they are patentable. The profit in the manufacture of plastics has been huge. Plastics are everywhere. Plastic manufacturing now uses 4% of the world's oil production annually. Automobiles are now 9% plastic. It is of my special concern that more foods and beverages are being put into plastic containers. Plastics are ubiquitous now. They persist and accumulate in our society as their production exceeds their chemical degradation rate. Harmful chemicals from plastics are now commonly found in groundwater, waterways, and drinking water. While standing out in the summer heat in Phoenix, Arizona in 1981, my girlfriend asked me what was causing the film to form on the inside of the windshield of her new Mazda 626. She said that she had to wipe it off every morning so she could see to drive to work. I didn't know then. I do now! It was phthalates, the chemical that was added to the plastic dash cover to soften it and prevent cracking. I'm sure by now most of the phthalate has evaporated into our atmosphere and the Mazda is in some junkyard with a cracked up dash. Phthalates are EDC's (Endocrine Disrupting Chemicals.) They are chemicals found in recycle codes #1 through #6 plastics. Another EDC (Bisphenol A) is in recycle code #7 plastics. All of these types of plastic EDC's interfere with the function of sex hormones receptors. In THE GRADUATE Benjamin was quite a stud. I wonder if he's now taking one of the popular drugs to treat erectile dysfunction, a disorder that has become one of the many epidemics in our new plastic world. In 2003 a group of Croatian scientists reported that phthalates in plastics dissolved in various solutions. They used a variety of plastic items, including plastic food containers. After 10 days of sitting in distilled water, an average of 55.4 mg/ of phthalates from each kilogram of plastic "migrated" into the water. To a lesser degree the phthalates from plastics dissolved into acetic acid 3% (44.4 mg/kg) and 10% ethyl alcohol (32.3 mg/kg). The Croatian study shows what Benjamin would suspect, if he took chemistry in college: Water is the universal solvent; and it dissolves even the primarily fat soluble phthalates. The more that you filter water to remove other toxic solutes, the more aggressive water becomes in its power to reach osmolar equilibrium by dissolving its non-inert containers. What is also obviously missing from the Croatians' controlled, static testing model are the temperature variations that the plastic bottled water product goes through to get from bottling point to the mouth of the consumer. Transport trucks probably reach a very high temperature in the non refrigerated cargo areas that carry PETE (recycle code #1 plastic) bottled water in the summer. Heat facilitates the dissolution of phthalates into the water. Then the bottles may be stored for a much longer time than 10 days prior to consumption. Furthermore, freezing the containers produces micro-fissures in the interior surface of the plastic bottle container as the water expands, exponentially exposing more solute surface area. Traumatic handling or any motion of the package will further enhance diffusion. Applying the laws of physics, all of these factors clearly by extrapolation will increase the water dissolution of the plastic containers. Fatty foods in plastic containers are even more problematic, as fats are absorbed differently and carry their phthalate solvents into our bodies more easily. Phthalates bio-accumulate because of their fat solubility. Phthalates concentrate in such fat organs in our bodies such as brains, prostates, testicles, ovaries, breasts and, unfortunately, breast milk. (The other popular food alternatives for infants are worse. Commercial baby formulas are loaded with the manmade phthalates.) I think the worst example of food containment in plastic is milk. All milk except non-fat milk contains fat. Cow milk itself represents a major source of the fats ingested by the public, especially children. Cattle concentrate these chemicals by bioaccummulation because EDC's from plastics are ubiquitous in water and most animal food sources. Meat and dairy products are therefore a major contributor to this group of human food chain derived toxins, regardless of their containment. It is now irresponsible to add more phathalates to the products by putting the milk products in plastic containers that add MORE EDC's. Cattle have intentially been "fattened up" by adding hormones AND unintentially "fattened up" more by the contamination of cattle food and water by EDC's. The combination of these chemicals passed on to the consumers in concentrated form in milk products will most likely exacerbate obesity in humans that consume them as well. Our current scientific knowledge and common sense screams for an end to consumer purchase of milk bottled in plastics. Until milk companies have their products quantatatively analysed for these EDC's by competent independant laboratories, my strong recommendation is to avoid purchase and consumption of milk and dairy products contained in plastic. Sadly, the Croatian authors' 2003 conclusions about the safety of plastics were: "These (exposure) levels would not present a hazard for human health, not even for a prolonged period of time." However, what was deemed acceptable levels of phthalates in 2003 now is recognized as "crystal clearly" too high. Selective interpretations from the ACC (American Chemistry Council) lead to this erroneously high level being "set" for past toxicity standards. The ACC is an "industry group" advisor. It's much like the wolf guarding the henhouse. Thanks to the ACC efforts, control regulations placed upon this chemical class are minimal. An ongoing perpetuation of phthalate approval for use in virtually everything, including containment of food, has resulted. In fact, the perpetuation of these mythological high safety standards has resulted in the majority of our food being wrapped or contained in plastics that leach EDC's into our foods. The ACC's Phthalate Esters Panel is made up representatives from BASF, Eastman Chemical, Exxon-Mobil Chemical, Ferro, and Teknor Apex Corporations. After graduating, Benjamin could have gone to work for any of these companies to share the wealth that plastics manufacturing have reaped, instead of hanging around and sporting Mrs. Robinson for the summer! I love one of the rationalization examples the ACC makes on their PHTHALATES INFORMATION CENTER webpage: "Thanks to phthalates, your nail polish doesn't chip." I wonder if they are aware of the "unexplained" high rate of breast cancer in manicurists. I also wonder if they are aware that most breast tissues and breast cancers have sex hormone receptors that are acted upon by the EDC's found in plastics. To further confuse the public, the ACC webpage also redefines the PRECAUTIONARY PRINCIPLE which in its un-perverted definition simply is: A (chemical) should not be considered safe until it is proven safe. Environmentalists who are trying to unravel the cause-effect relationships of environment chemicals, to the otherwise unexplained epidemics of various diseases now affecting man as well as every species on our planet, encourage its application. The ACC's watered down version suggests that cost effective, fearless risks are worth taking. Can the ACC keep up the phthalate safety illusion forever? The American Tobacco Association almost got away with it! We now know that EDC's, like hormones themselves require very minute amounts to have physiologic impact. EDC's are active in parts per trillion! For example, the usual adult maintenance dose of levothyroxine, a drug to replace depleted natural thyroid hormone in hypothyroidism, is 1.6 micrograms/Kg/day. Why would I even think about saying that a dose in the milligrams (1000 times as much as a microgram) of a known EDC would be safe, especially for a child or developing fetus? We now know that phthalates also work in synergy with chemicals in other classes to exert "more than additive" physiologic effects. Previous experiments in rodents showed that high levels of phthalates interfer with testosterone during gestation resulting in birth defects of the genitalia, testicular cancer, and infertility in the rats. The ACC inspired acceptable level of phthalate myth should be blown out of the water with a recent study completed by the University of Rochester School of Medicine and Dentistry. This study of 85 human infant boys reported in May 2005 showed that phthalate levels found normally in the general population adversely influenced sexual development. The phthalate exposure these children had correlated with smaller penis size and incomplete testicular descent, which is a condition that greatly increases the risk of testicular cancer if left untreated. Solution 1 - Choose glass containers over plastic for purchase and storage of food and beverages including milk and water. American children can consume several milligrams of phthalate each day. I wonder if THE GRADUATE's Mr. Robinson noticed that most of the teenage girls now-days have bigger breasts than his seductive wife (gynecomastia), and that they begin thelarche (breast development) and menarche (menstruation) at a significantly younger age, or that many more have an endocrine pathology called PCOS (polycystic ovary syndrome). The chances of a woman getting breast cancer in her lifetime has probably gone from a risk of less than 1 in 10 (10%) before THE GRADUATE was made to a 1 in about 7.5 (13.2 %) rate today. The choice to avoid food chain plastics is a "no-brainer" when you understand how these chemicals persist and accumulate in our environment, and how they function in our bodies! Solution 2 - Choose stainless steel containers over plastic for storage of food and beverages including water. Unfortunately, we are past the point of no return with phthalates. Just like cigarettes I think we'll have to live as prisoners with their impact on future generations. The only defense we have at this time is to individually choose to avoid them when we can, to mitigate their effects on our health. Phthalates clearly act upon hormone receptors in both men and women. A concern is the potential phthalate impact on breast and other hormone sensitive tissue in human females, but phthalate's demasculinizing potential on males is more of a threat to all species on the planet. Unlike Mr. McGuire, I think we can choose a better future by avoiding his "one word." We should start by trying to reduce plastics in our food chain exposures. Bottom line: I would strongly advise consumers to purchase beverages and non-solid food products packaged in glass rather than plastic if given the choice. © Life Dynamix 2005 All Rights Reserved penis enargement pic penis elargement result penis elargement review penile enlargement surgery picture safe penis enlargement cheap penis enlagement pills penis elargement traction device penile enlargement photo buy penis enlargement pill

The Complications associated with Primary Pulmonary Hypertension can lead to fatal consequences in patients afflicted by this progressive lung disorder. However, there is no reason for despair. The situation may be grave but a variety of treatments are now available, aiming at prevention or even curing of Primary Pulmonary Hypertension-related Complications. A serious Complication may be blood clots. Blood clot formation where there is no need for it can turn fatal. If there are clots in the small arteries of the lungs then this can pose a threat by disturbing the already narrowed or blocked blood vessels, thereby terminating normal blood circulation to the lungs. This undesirable clotting or coagulation of blood can be remedied by the use of anti-coagulants. However, it must be remembered that anti-coagulants have their own risks and benefits, which need to be carefully considered by a doctor prior to administration. Fluid build-up in the body may be another complication. Two kinds of edemas- pedal edema (fluid accumulation in legs) and ascites (fluid accumulation in abdomen) are among such Primary Pulmonary Hypertension Complications. Pulmonary edema may also develop as a complication, whereby the lungs fill with accumulated fluid. This may even prove to be fatal, as the accumulated fluid can hamper the proper exchange of oxygen and carbon dioxide in the lungs. As medication for such edema, diuretics are helpful. A less-fluid, low-sodium diet may also manage the risks of such complications. The enlargement of the heart’s right ventricle, leading to its functional failure, is among the most serious of the Primary Pulmonary Hypertension Complications. This might even lead to a complete failure of the heart. Several drug treatments come in aid of these complications- digoxin therapy, vasodilators, calcium channel blockers; endothelin receptor antagonists and oxygen therapies are carried out as treatment. It may be that a lung transplant proves a workable solution for the prevention or treatment of Primary Pulmonary Hypertension Complications.